To better characterize PR or PR-like reactions after COVID-19 vaccination, we conducted a review of the medical literature. We searched the PubMed database for articles, including case reports and case series, using the following search terms: COVID-19 vaccine, coronavirus 2019 vaccine, SARS-CoV-2 vaccine, pityriasis rosea, and pityriasis rosea–like reaction. Pityriasis rosea (PR) is a self-limited disease; treatment is supportive. Drug therapy for pityriasis rosea primarily consists of symptomatic treatment of pruritus. Topical zinc oxide and calamine lotion may be helpful. Oral antihistamines and topical corticosteroids can be used as needed. Pityriasis rubra pilaris is a rare skin disorder that causes skin inflammation and shedding. such as lichen planus and pityriasis rosea. A stress-induced rash isn’t always a cause for Another suspected trigger is stress and the condition, regardless of the cause implicated, is not suspected until therapies used for closely related conditions have failed. Pityriasis rosea is Fashion advice. Clothing can be one of the most stressful decisions for someone with psoriasis. You want to wear tank tops and shorts, but might be too uncomfortable. Maybe long sleeves irritate your skin. Try looking for softer, loose-fitting fabrics that look great and let your skin breathe. Now learn How to Talk About Psoriasis. The cause of pityriasis rosea is debated as of early 2004. Various researchers have reported isolating a mycoplasma (a type of gram-negative bacterium), a picornavirus, and human herpesviruses 6 and 7 from skin samples of patients diagnosed with the disease, but these findings are not yet considered definitive. The cause of PR is unknown but many dermatologists hypothesize that it is caused by a virus with Human Herpesvirus 6 (HHV 6) and Human Herpesvirus 7 (HHV 7) as the primary suspects. The viral etiology is supported by the fact that some patients experience a mild viral like prodrome prior to the rash appearing and some studies have revealed HHV PITYRIASIS ROSEA osms.it/pityriasis-rosea PATHOLOGY & CAUSES Self-limiting acute dermatosis Unknown etiology; may be viral in origin, related to human herpesvirus 7 (HHV7) SIGNS & SYMPTOMS Upper respiratory tract infection may precede rash “Herald patch” Solitary oval red plaque, usually located on trunk First skin lesion Spreads with tG85.